Liquid clenbuterol, also known as clenbuterol hcl, A beta 2-AGONIST, is a potent selective bronchodilator that initially was used as a drug to treat bronchospasm and to alleviate the symptoms of chronic obstructive pulmonary disease (COPD) in the horse.
Several investigators have studied the effect of short-term (either acute or 5.5 days) clen hcl treatment on various cardio-respiratory functions in a variety of horse breeds.
Interestingly, chronic (1-8 wk) administration has also been shown to elicit a muscle-directed protein anabolic response in a variety of species when used in higher than therapeutic doses. Specifically, clenbuterol has been used as an agent to increase muscle mass, body weight, and muscle protein synthesis rate. This repartitioning of nutrients to alter body composition has been shown to have a profound effect on the production of meat animals.
Lambs fed on it demonstrated improved feed conversion, reduced fat deposition, and increased muscle deposition. Similar improvements in muscle accretion and fat reduction were seen in both steers and broilers fed liquid clenbuterol.
Clenbuterol As A Repartitioning Agent
Given the fact that it may be prescribed as a liquid it may be prescribed for extended periods to alleviate bronchospasm or COPD in horses and that chronic use of it alters body composition in other species, it is reasonable to predict that it may act as a repartitioning agent in the horse. Horses using clenbuterol may still be physically active or training while being treated with it. Unfortunately, it has been shown to be antagonistic to exercise capacity.
Furthermore, there are no data examining the interaction of exercise training and clenbuterol with regard to body composition in any species, including humans and horses. It is frequently abused by human athletes, especially females, because its repartitioning effects are not associated with the androgenic side effects of steroids.
Therefore, the purpose of this study was to test the hypothesis that 8 wk of clenbuterol, administered at therapeutic levels, with and without exercise training, would produce repartitioning effects in horses.
It’s effects can be projected to be significant when applied in the near term, but long term use sees a drop off of effectiveness. A rest period equal to the active intake period is necessary and it may require an offset compound such as ketotifen to “reset” the beta 2 receptors. Prolonged application of clenbuterol is not recommended as damage to research subjects has been identified.
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